Salinomycin in är endast tillåtet i vissa fjäderfäfoder och kan vara skadligt för andra djurslag. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

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The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is … Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage.

Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. IC50 Value:; Target: Antibacterial; Anticancer; Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/?-catenin signaling pathway, and other CSC pathways[1].; in vitro: Salinomycin acts as a potassium ionophore and thereby interferes with References General References.

Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens.

/ Borgström, Björn. Lund : Lund University, Faculty of Science, Department of Chemistry, Centre for Analysis and Synthesis, 2016. 69 p. Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants.
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Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Salinomycin, a commercially significant coccidiostat isolated from , has been synthesised from three principal fragments.

The method is not applicable to drug premixes (pharmaceutical products).
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For feed manufacturing use only The ability of salinomycin to kill both cancer stem cells and therapy-resistant cancer cells (persister) may define the compound as a novel and an effective anticancer drug. It has been also shown that salinomycin and its derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Salinomycin reduces the proportion of cancer stem cells (CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Detailed Study on the Global Salinomycin Premix Market. A recent market study throws light on some of the leading factors that are likely to influence the growth of the Salinomycin Premix market in the upcoming decade. SALINOMYCIN SODIUM. Salinomycin sodium salt.